to leave in the lurch, to let someone down
Precisava muito daquele dinheiro que emprestei ao meu sobrinho, mas ele me deixou na mão!
I really needed the money I’d lent my nephew, but he let me down!
The picture in deixar na mão ("to leave in the hand") is the mirror image of lending a hand: someone holds out an open hand for the help they were promised, and the other person walks away, leaving them with nothing but their own outstretched hand.
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