Meaning
No way; by no means; absolutely not. Used to emphatically deny or refuse something.
Example
— Você vai desistir do curso? — De maneira nenhuma! Vou até o fim.
— Are you going to drop the course? — No way! I'm going all the way.
Origin
A common emphatic negation in Brazilian Portuguese, equivalent to "de jeito nenhum" or "de forma alguma".
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More idioms
dê seus pulosFigure it out yourself, manage on your ownser laranjaTo be a front man, to lend one's name for illegal or fraudulent activitiesse desenmerdarTo sort things out on one's own, to get oneself out of trouble (vulgar)dar broncaTo scold, to give someone a telling-offBora láInformal expression meaning "let's go!" or "come on, let's do it!"Chá de casa novaHousewarming party — a celebration to inaugurate a new home, where guests bring useful household gifts.Acertar na moscaTo guess correctly / To hit the nail on the headAmigo da onçaA fake/false friendAndar na linhaTo toe the line / To behave properlyArmar um barracoTo cause a public scene